NASA Spaceline Current Awareness List #862 23 August 2019 (Space Life Science Research Results) – Space Ref

August 23, 2019

Status Report From: Spaceline
Posted: Friday, August 23, 2019

SPACELINE Current Awareness Lists are distributed via listserv and are available on the NASA Task Book website athttps://taskbook.nasaprs.com/ Publication/spaceline.cfm. Please send any correspondence to Robyn Ertwine, SPACELINE Current Awareness Senior Editor, SPACELINE@nasaprs.com.

Papers deriving from NASA support:

Jiang P, Green SJ, Chlipala GE, Turek FW, Vitaterna MH.

Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight.

Microbiome. 2019 Aug 9;7(1):113.

https://www.ncbi.nlm.nih.gov/ pubmed/31399081

PI: F.W. Turek

Note: ISS results. This article may be obtained online without charge.

Journal Impact Factor: 10.465

Funding: “This project is supported by NASA under the grant number NNX15AL05G.”

Sibonga J, Matsumoto T, Jones J, Shapiro J, Lang T, Shackelford L, Smith SM, Young M, Keyak J, Kohri K, Ohshima H, Spector E, LeBlanc A.

Resistive exercise in astronauts on prolonged spaceflights provides partial protection against spaceflight-induced bone loss.

Bone. 2019 Aug 7. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31400472

PI: J. Sibonga

Note: ISS results.

Journal impact Factor: 4.360

Funding: “The research reported in this paper was funded by the National Aeronautics Space Administration (NASA) and the Japan Aerospace Exploration Agency (JAXA).”

Zwart SR, Laurie SS, Chen JJ, Macias BR, Lee SMC, Stenger M, Grantham B, Carey K, Young M, Smith SM.

Association of genetics and B vitamin status with the magnitude of optic disc edema during 30-day strict head-down tilt bed rest.

JAMA Ophthalmol. 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31415055

PIs: S.S. Laurie, S.M. Smith

Note: Head-down tilt bed rest study.

Journal Impact Factor: 6.167

Funding: “This work was supported by the National Aeronautics and Space Administration Human Research Program’s Human Health Countermeasures Element.”

Mortreux M, Ko FC, Riveros D, Bouxsein ML, Rutkove SB.

Longitudinal time course of muscle impairments during partial weight-bearing in rats.

npj Microgravity. 2019 Aug 22;5(1):20.

https://www.nature.com/ articles/s41526-019-0080-5

PI: S.B. Rutkove

Note: Hindlimb unloading study. This article may be obtained online without charge.

Journal Impact Factor: 3.111

Funding: “This work was funded by the National Aeronautics and Space Administration (NASA: NNX16AL36G).”

Williams MA, Malm J.

Mischaracterization of spaceflight-associated neuro-ocular syndrome.

JAMA Neurol. 2019 Aug 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31403660

Note: The authors comment on: Roberts DR, Petersen LG. Studies of hydrocephalus associated with long-term spaceflight may provide new insights into cerebrospinal fluid flow dynamics here on Earth. JAMA Neurol. 2019 Apr 1;76(4):391-392. Epub 2019 Jan 23. https://www.ncbi.nlm.nih.gov/ pubmed/30673794. The Roberts/Petersen article was an editorial comment on: Lee JK, Koppelmans V, Riascos RF, Hasan KM, Pasternak O, Mulavara AP, Bloomberg JJ, Seidler RD. Spaceflight-associated brain white matter microstructural changes and intracranial fluid redistribution. JAMA Neurol. 2019 Apr 1;76(4):412-419. Epub 2019 Jan 23. https://www.ncbi.nlm.nih.gov/ pubmed/30673793. Both articles were cited in SPACELINE Current Awareness List #834, 1 Feb 2019.

Journal Impact Factor: 12.321

Funding: No funding cited. M.A. Williams discloses current NASA funding.

Roberts DR, Petersen LG.

Mischaracterization of spaceflight-associated neuro-ocular syndrome—Reply.

JAMA Neurol. 2019 Aug 12. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31403662

Note: The authors reply to #5 above: Williams MA, Malm J. Mischaracterization of spaceflight-associated neuro-ocular syndrome. JAMA Neurol. 2019 Aug 12. [Epub ahead of print] https://www.ncbi.nlm.nih.gov/ pubmed/31403660.

Journal Impact Factor: 12.321

Funding: No funding cited. Both authors disclose current NASA funding.

Rahman SA, Grant LK, Gooley JJ, Rajaratnam SMW, Czeisler CA, Lockley SW.

Endogenous circadian regulation of female reproductive hormones.

J Clin Endocrinol Metab. 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31415086

PIs: C.A. Czeisler, S.W. Lockley

Journal Impact Factor: 5.605

Funding: “This work was supported by the National Institute of Mental Health (2R01 MH45130-11A1 Czeisler/Lockley), the National Center for Complementary and Alternative Medicine (R01 AT002129 Czeisler/Lockley) and the National Institute of Environmental Health Sciences (R21 ES017112-01A1 Lockley). C.A.C. and S.W.L. were supported in part by the National Space Biomedical Research Institute through NASA NCC 9-58. The project was supported by Brigham and Women’s Hospital General Clinical Research Center grant (M01-RR02635).”

Ivkovic V, Sommers B, Cefaratti DA, Newman G, Thomas DW, Alexander DG, Strangman GE.

Operationally relevant behavior assessment using the Robotic On-Board Trainer for Research (ROBoT-r).

Aerosp Med Hum Perform. 2019 Sep 1;90(9):819-25.

https://www.ncbi.nlm.nih.gov/ pubmed/31426899

PI: D.F. Dinges

Journal Impact Factor: 0.889

Funding: “This study was supported by NASA grant NNX15AK76A.”

Alexander AM, Sutterfield SL, Kriss KN, Hammer SM, Didier KD, Cauldwell JT, Dzewaltowski AC, Barstow TJ, Ade CJ.

Prediction of emergency capsule egress performance.

Aerosp Med Hum Perform. 2019 Sep 1;90(9):782-7.

https://www.ncbi.nlm.nih.gov/ pubmed/31426893

PI: T.J. Barstow

Journal Impact Factor: 0.889

Funding: “This study was supported by grant NNX16AF66A from the National Aeronautics and Space Administration to C. J. Ade and T. J. Barstow.”

Scully RR, Garcia H, McCoy JT, Ryder VE.

Revisions to limits for methanol in the air of spacecraft.

Aerosp Med Hum Perform. 2019 Sep 1;90(9):807-12. Review.

https://www.ncbi.nlm.nih.gov/ pubmed/31426897

Journal Impact Factor: 0.889

Funding: No funding cited. V.E. Ryder is affiliated with NASA Johnson Space Center.

______________________________ ________________________

Other papers of interest:

Bai P, Zhang B, Zhao X, Li D, Yu Y, Zhang X, Huang B, Liu C.

Decreased metabolism and increased tolerance to extreme environments in Staphylococcus warneri during long-term spaceflight.

Microbiologyopen. 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31414557

Note: Shenzhou-10 results. This article may be obtained online without charge.

Wood KN, Greaves DK, Hughson RL.

Inter-relationships between pulse arrival time and arterial blood pressure during postural transitions before and after spaceflight.

J Appl Physiol (1985). 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31414954

Note: ISS results.

Eyal S, Derendorf H.

Medications in space: In search of a pharmacologist’s guide to the galaxy.

Pharm Res. 2019 Aug 14;36(10):148. Review.

https://www.ncbi.nlm.nih.gov/ pubmed/31414302

Note: ISS results are reviewed.

Kim AB, Milsom WK.

pH regulation in hibernation: Implications for ventilatory and metabolic control.

Comp Biochem Physiol A Mol Integr Physiol. 2019 Nov;237:110536. Epub 2019 Aug 8.

.0.0 Review.

https://www.ncbi.nlm.nih.gov/ pubmed/31401311

Yamada S, Kamata T, Nawa H, Sekijima T, Takei N.

AMPK activation, eEF2 inactivation, and reduced protein synthesis in the cerebral cortex of hibernating chipmunks.

Sci Rep. 2019 Aug 15;9(1):11904.

https://www.ncbi.nlm.nih.gov/ pubmed/31417118

Note: This article may be obtained online without charge.

Buken C, Sahana J, Corydon TJ, Melnik D, Bauer J, Wehland M, Kruger M, Balk S, Abuagela N, Infanger M, Grimm D.

Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity.

Sci Rep. 2019 Aug 15;9(1):11882.

https://www.ncbi.nlm.nih.gov/ pubmed/31417174

Note: A random positioning machine was used. This article may be obtained online without charge.

Chen L, Liu G, Li W, Wu X.

Sonic hedgehog promotes chondrogenesis of rabbit bone marrow stem cells in a rotary cell culture system.

BMC Dev Biol. 2019 Aug 12;19(1):18.

https://www.ncbi.nlm.nih.gov/ pubmed/31401976

Note: A rotary cell culture system was used. This article may be obtained online without charge.

Salerni F, Repetto R, Harris A, Pinsky P, Prud’homme C, Szopos M, Guidoboni G.

Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions.

PLoS One. 2019 Aug 14;14(8):e0216012.

https://www.ncbi.nlm.nih.gov/ pubmed/31412033

Note: From the Abstract: “This work aims at investigating the interactions between the flow of fluids in the eyes and the brain and their potential implications in structural and functional changes in the eyes of astronauts, a condition also known as spaceflight associated neuro-ocular syndrome (SANS). To this end, we propose a reduced (0-dimensional) mathematical model of fluid flow in the eyes and brain, which is embedded into a simplified whole-body circulation model. In particular, the model accounts for: (i) the flows of blood and aqueous humor in the eyes; (ii) the flows of blood, cerebrospinal fluid and interstitial fluid in the brain; and (iii) their interactions. The model is used to simulate variations in intraocular pressure, intracranial pressure and blood flow due to microgravity conditions, which are thought to be critical factors in SANS.” This article may be obtained online without charge.

Cacao E, Cucinotta FA.

Meta-analysis of cognitive performance by novel object recognition after proton and heavy ion exposures.

Radiat Res. 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31415222

Cucinotta FA, Smirnova OA.

Response of human small intestinal epithelium to fractionated irradiation: Dynamical modeling approach.

Radiat Res. 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31415223

Chen L, Zhang B, Yang L, Bai YG, Song JB, Ge YL, Ma HZ, Cheng JH, Ma J, Xie MJ.

BMAL1 disrupted intrinsic diurnal oscillation in rat cerebrovascular contractility of simulated microgravity rats by altering circadian regulation of miR-103/CaV1.2 signal pathway.

Int J Mol Sci. 2019 Aug 14;20(16):E3947.

https://www.ncbi.nlm.nih.gov/ pubmed/31416128

Note: Hindlimb unloading study. This article may be obtained online without charge.

Slungaard E, Pollock RD, Stevenson AT, Green NDC, Newham DJ, Harridge SDR.

Aircrew conditioning programme impact on +Gz tolerance.

Aerosp Med Hum Perform. 2019 Sep 1;90(9):764-73.

https://www.ncbi.nlm.nih.gov/ pubmed/31426891

Note: A human centrifuge was used.

Coleman ML.

An anesthesiologist in the space race: The life and career of Dr. Cloid D. Green.

J Anesth Hist. 2019 Apr;5(2):44-8.

https://www.ncbi.nlm.nih.gov/ pubmed/31400835

Note: Dr. Green was the NASA project officer charged with development of a life support system for Project Mercury primate flights.

Song Y, Li G, Nowak J, Zhang X, Xu DB, Yang X, Huang G, Liang W, Yang L, Wang C, Bulone V, Nikoloski Z, Hu J, Persson S, Zhang D.

The rice actin-binding protein RMD regulates light-dependent shoot gravitropism.

Plant Physiol. 2019 Aug 15. [Epub ahead of print]

https://www.ncbi.nlm.nih.gov/ pubmed/31416828

Note: This article may be obtained online without charge.

Shen Y, Guo S, Zeng G.

Effects of a new-type inner-canopy illuminant and light quality on spring wheat growth in CELSS.

Acta Astronaut. 2019 Aug 19. [Article in Press]

http://www.sciencedirect.com/ science/article/pii/ S0094576519312020

Pletser V, Evetts S, Vickers J, Parazynski S.

Commercial spaceflight preparation and extravehicular activities training: The next generation.

New Space. 2019 Aug 9. [Article in Press]

https://www.liebertpub.com/ doi/abs/10.1089/space.2019. 0019

Note: From the abstract: “This article outlines the facilities, training curricula, and future aspirations for the Blue Abyss commercial spaceflight preparation services.”

Law KE, Lowndes BR, Kelley SR, Blocker RC, Larson DW, Hallbeck MS, Nelson H.

Surgeon workload in colorectal surgery: Perceived drivers of procedural difficulty.

J Surg Res. 2019 Aug 8;245:57-63.

https://www.ncbi.nlm.nih.gov/ pubmed/31401248

Note: The NASA Task Load Index was used.

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